ABSTRACT
Phototherapy with photochemotherapy (PUVA) is a well‑known and well‑studied modality for the treatment of psoriasis, which involves systemic or topical administration of chemicals known as psoralens and administration of ultraviolet light in increasing dosages after requisite time gap. PUVA is also used in the treatment of widespread vitiligo with moderately good results, though it is being surpassed by ultraviolet B (UVB), which is equally or slightly more efficacious with fewer side effects. PUVA induces repigmentation by varying mechanisms such as stimulation of melanogenesis, immunomodulation and activation of growth factors, though the exact mechanism is still speculative. There are various studies evaluating the efficacy of PUVA in psoriasis as well as in vitiligo, either alone or in combination with other immunosuppressants like azathioprine and calcipotriene.
Subject(s)
Furocoumarins/administration & dosage , Furocoumarins/therapeutic use , Humans , Photochemotherapy/methods , Psoriasis/drug therapy , Psoriasis/radiotherapy , Psoriasis/therapy , Ultraviolet Rays/administration & dosage , Ultraviolet Rays/therapeutic use , Vitiligo/drug therapy , Vitiligo/radiotherapy , Vitiligo/therapySubject(s)
Glycolates/administration & dosage , Male , Middle Aged , Ochronosis/diagnosis , Ochronosis/drug therapySubject(s)
Female , Fluorescent Antibody Technique , Humans , Middle Aged , IgA Vasculitis/pathologySubject(s)
Adult , Antifungal Agents/therapeutic use , Cheek , Chin , Erythema/etiology , Face , Humans , Itraconazole/therapeutic use , Male , Pruritus , Tinea/complicationsABSTRACT
BACKGROUND: Paddy farming is one of the main occupations in coastal South India. Dermatological problems in paddy field workers have not received much attention. AIM: The purpose of this study was to study the dermatoses of the exposed parts of the body, viz. face, hands, and feet, in paddy field workers. METHODS: Three hundred and forty-one workers were questioned and clinical findings noted. Scrapings for bacterial and fungal examination were taken by random selection. RESULTS: Seventy-three per cent had work-related itching. Melasma was the commonest facial lesion (41.1%). The main problems on the hands were hyperkeratosis (26.4%), nail dystrophy (15.2%) and paronychia (8.8%). Common feet dermatoses included nail dystrophy (57.1%), pitted keratolysis (42.5%) and fissuring (23.5%). Common aerobic and anaerobic bacteria isolated from pitted keratolysis and intertrigo were Klebsiella and Clostridium species. Aspergillus species were the commonest fungus grown from intertrigo. CONCLUSIONS: Occupational dermatoses are common in paddy field workers.
Subject(s)
Adolescent , Adult , Age Distribution , Agriculture , Confidence Intervals , Cross-Sectional Studies , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Female , Foot Dermatoses/diagnosis , Hand Dermatoses/diagnosis , Humans , India/epidemiology , Male , Middle Aged , Pilot Projects , Prevalence , Severity of Illness Index , Sex DistributionABSTRACT
Photopatch testing with Scandinavian photopatch series was done in 50 patients with photodermatitis. The frequent photosensitisers were musk ambrette, chlorpromazine, promethazine, and PABA.